Data
Year of publication
2020
Kind
Quantitative
Design
Longitudinal
Classification
NOVA
Country studied
Italy
Data
Primary
Data collected
One ood frequency
Study setting
Household
Age group of participants
Adults/35 and older
Participant sex
Mixed
Target population
General
Sample size
n=22810 (participants)
Consumption of ultra-processed foods and beverages is associated with increased risk of cardiovascular mortality in the moli-sani study cohort
goal
Find association between UPFB consumption and mortality risk in a large sample of the Italian population and tested whether some known cardiovascular disease (CVD) risk factors and nutrients could be on the pathway of this relation.
Results
Over a median follow up of 8.3 y, 1,235 deaths were ascertained. As opposed to lower intake (<2 servings/d), individuals reporting high intake of UPFB (>4 servings/d) experienced an increased risk of CVD mortality (HR=1.50; 95%CI 1.18-1.92) and of death for ischemic heart (IHD)/cerebrovascular disease (1.56; 1.13-2.14). An upward trend was found for all-cause mortality too (1.15; 1.00-1.34). Biomarkers of renal function (cystatin C and creatinine) or of lipid metabolisms were likely to be on the pathway between UPFB and CVD mortality. Among selected macronutrients, high content of sugar and saturated fats possibly drove the relation of UPFB with CVD mortality. High intake of ‘healthy’ UPFB was associated with an increased trend of risk comparable to that associated with ‘unhealthy’ UPFB.
Authors
Bonaccio M, Di Castelnuovo AF, Costanzo S, Curtis A, Persichllo M, et al.
Log
Circulation
DOIs